Mr Calcu | Easily estimate kidney function to support safer, more precise treatment decisions—fast, accurate, and clinically trusted.

Quickly calculate creatinine clearance using the Cockcroft-Gault equation. Empower your clinical decisions and protect patient safety with confidence.

Creatinine Clearance Estimator Description

Understanding Creatinine Clearance

Creatinine clearance (CrCl) estimates the glomerular filtration rate (GFR), representing the kidney's capacity to clear creatinine from blood plasma. It plays a vital role in evaluating kidney function and determining proper drug dosing.

Core Formula

CrCl (mL/min) = [(140 - age) × weight (kg)] / (72 × serum creatinine in mg/dL)

Female Adjustment:

CrCl_female = CrCl_male × 0.85

Comparison with GFR Equations

• Cockcroft-Gault: Best for drug dosing.
• MDRD/CKD-EPI: More accurate for diagnosing chronic kidney disease.

Weight Considerations

For obese patients, use adjusted body weight:

AdjBW = IBW + 0.4 × (TBW - IBW)

• IBW (Ideal Body Weight): Males: 50 + 2.3 × (height in inches - 60)
  Females: 45.5 + 2.3 × (height in inches - 60)
• TBW: Total Body Weight in kilograms

Mini Case Study 1: Elderly Female

Patient: 78 years old, 52 kg, serum creatinine = 1.0 mg/dL

CrCl = [(140 - 78) × 52] / (72 × 1.0) × 0.85 = 37.1 mL/min

Her CrCl is significantly reduced, influencing drug therapy decisions.

Mini Case Study 2: Obese Male

Patient: 45 years old, 120 kg, 70 inches, serum creatinine = 1.2 mg/dL

IBW = 50 + 2.3 × (70 - 60) = 73 kg
AdjBW = 73 + 0.4 × (120 - 73) = 91.8 kg
CrCl = [(140 - 45) × 91.8] / (72 × 1.2) ≈ 101.5 mL/min

Using TBW would have incorrectly estimated CrCl at ~133 mL/min.

Take action now: Use this calculator to optimize renal dosing and make confident, patient-safe decisions—every time.